I saw a GP about it (not my usual one) and they strongly suspect it is being caused by MTX but I have just spoken to the Rheumy nurse who thinks Hydroxy is the more likely suspect or it may be an autoimmune response so now I have to withhold all rheumy meds. It seems to improve when I am on steroids but only at higher doses. Thanks, Tamara I am on all sorts of meds including MTX and Hydroxy. Hydroxychloroquine vision side effects Hydroxychloroquine for leg cramps Plaquenil is most often well-tolerated but, like with any drug, side effects are possible. Most people about 90% who take antimalarial medications experience no side effects. If common side effects do occur, they are usually minor and last only for a short period of time. How does Plaquenil work? Surprisingly, the reason for its success in lupus still remains somewhat mysterious. It has a wide variety of known effects – aspirin-like anti-inflammatory, mild immunosuppressive and mild cholesterol lowering amongst others. Perhaps an important property is that of sun-protection. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. I can't face the GP again, as I am sure I am one of the "heart-sink" patients! I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! What does a plaquenil rash look like Rheumatoid arthritis rash Causes, symptoms, and images, Plaqunil rash - Plaquenil alcohol interactionChloroquine phosphate solubility storage If it continues to happen, I will look into switching to the real deal plaquenil. Right now, I do think the medication is helping me. It has been a long time since I have been able to twirl my wedding rings around on my fingers. My swelling is gone! I am still waking up with a little stiffness, but not bad and no pain like before. Immune & Autoimmune - Lupus Anyone Get An Itchy Rash From. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Skin rash 68 pictures, causes, and treatments. While hydroxychloroquine is considered a relatively safe medication, like all medications there are potential risks. These include body rashes that often will itch. The rash typically occurs in the first 6 weeks and is usually mild. In general, the rash will resolve within 2 weeks after stopping the drug. Aug 26, 2013 Yes. Hair bleaching, hair loss, skin pigmentation, rash and itching are recognized skin adverse reactions of plaquenil hydroxychloroquine. These reactions tend to be worse if a patient is taking other medications that have similar skin toxicity. Please consult a dermatologist to ensure skin lesions are not psoriatic because Plaquenil hydroxychloroquine use needs special precautions in. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year.