Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine tablets ip hcqs-400 Plaquenil manufacturer mylan pharmaceuticals inc assist Side effects of plaquenil on the eyes Can plaquenil cause low white blood cell count Hi. I have been taking Plaquenil since July 9, 2006 6 weeks and I do not notice results so far. For those of you who have taken it, how long does it take to work and how will I know it's starting to work? I really appreciate your response. I have arthritis in my feet and ankles. I still take Tylenol but my Hi - I just started Plaquenil 400 mg a day two week ago and I started feeling less achy and tired a few days ago. Is it possible for it to work quicker in some people? I've heard it can take months, but I must say that I haven't felt like this since I was a kid - not achy or stiff. Has anyone had a similar It takes a really long time for the Plaquenil to kick in. It may even take a year. Mine didn't start working until I was on it for 8 months and I take more than you do. I take 200 mg twice a day. I initially started at 800mg a day then dropped it to 400 mg a day. Please don't give up, you will have good days and bad days. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long does it take for plaquenil to kick in Hydroxychloroquine how long to take effect? - NRAS, Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly? Dose of hydroxychloroquine for raHydroxychloroquine eye examEffects of plaquenil on hairChloroquine and psoriasisChloroquine prescription She said we could try Plaquenil - a milder drug. I was told it takes two months before patients feel any improvement, it took little less for the drug to kick in. Now, it's been a year - I have no flares, no pain and no side effects I can think of. I take one pill in the morning, one in the evening. This drug works well for me." Plaquenil User Reviews for Rheumatoid Arthritis at. What is the correct way to discontinue use of plaquenil?. How long until Plaquenil started working?. I came across this page having the same question. How long does it take for Plaquenil to leave your system after discontinuing use. However, I do not want to stop taking it because of terrible side effects listed by other users of the med. I love this drug. I have never felt as good as I do now. Yep, I was just like you the first time I was taking Plaquenil. "Hurry up, show me". Well, I got really upset about 5 1/2 months into it and stopped taking it. I thought, "If this isn't going help, I am not going to take it". Well, about 2 weeks into my "stop" program, I suddenly realized it was helping me. By the time I recognize that I'm getting a flare I think because I was so sick for so long I've learned to ignore it until it's too late and take my first six-pill dose of a medrol pack, it takes a good 24 hours for me to get relief. But I do automatically feel better immediately because I know relief is coming!