Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil and shortness of breath Hydroxychloroquine 200mg Plaquenil sore more Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Hydroxychloroquine is also a disease-modifying anti-rheumatic drug DMARD that has immunomodulatory and anti-inflammatory effects. The exact hydroxychloroquine mechanism of action is unclear, although it does work to interrupt the communication of immune system cells to decrease swelling, pain, and joint damage. 1, 2, 3, 5 Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine in rheumatoid arthritis mechanism of action REFERENCES - UpToDate, RA and Hydroxychloroquine How Effective is it for Rheumatoid. Side effects of plaquenil withdrawalAralen online bible Hydroxychloroquine is an antimalarial drug. It treats malaria by killing the parasites that cause the disease. It isn’t fully understood how this drug works to treat lupus erythematosus or. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Plaquenil Success, Reviews and Side.. Hydroxychloroquine Information for Providers AIDSinfo. What is the mechanism of action for hyd. How long does it take for symptoms to i. What are the most common side effects o. When does hydroxychloroquine cause anem. Unclear. Probably interferes with communication of immune cell. Can start to see improvement in 1-2 months but 6 months are re. Nausea and diarrhea. Small amounts of hydroxychloroquine can be found in breastmilk, but international experts indicate this medication is acceptable while breastfeeding. MECHANISM OF ACTION. Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis.