I do have anxiety disorder but have not had a panic attack in two years and certainly not waves of panic. I have since lost my appetite and can only eat a little. Plaquenil genetic risk test Plaquenil false positive Chloroquine astrocytoma Plaquenil financial assistance I can only speak for myself and my personal experience. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens. I have not noticed an increase in depression/anxiety since being on the plaquenil but that is just me. Hi Deb, Yes, Plaquenil causes me serious anxiety. So I have tried different dosage with no success. Honestly, the doctors don't get it, but that doesn't matter to me. I was also tired and my joints were sore so I went back up to my original dose of 400mg but immediately experienced severe and sudden anxiety and depression. I am also on 150mg of zoloft for GAD, OCD and depression which I have largely had under control for the past ten years with occasional little hiccups, but this has really shook me. This didn't make me happy because I really feel that looking for more medication from someone else for sudden symptoms is not a wise choice. It helped me sleep but makes me way too tired during the day -- so it is like I am anxious, panicky, and exhausted now. She said right away that she does not think it is the plaquenil and then suggested I see a psychiatrist. Plaquenil anxiety depression Does Plaquenil affect your temperament? - LUPUS UK, Plaquenil, anxiety and depression, Buy aralen 500mgHydroxychloroquine with lamotrigine with oxycodonePlaquenil ear problemsCan i eat grapefruit on plaquenilChloroquine tablets uk After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day. I have always been very sensitive to meds. Again my fatigue improved and I began to be able to do more. But again- over several months time my anxiety, depression, and sense of distance from personal relationships began to worsen. Plaquenil and Depression/Anxiety - Symptoms and Medical.. Plaquenil and anxiety/depression? - Inspire. Plaquenil Side Effects Of Bipolar And Depression.. View detailed reports from patients taking Hydroxychloroquine Sulfate who experienced anxiety. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. I was on Plaquenil for a few days and I had severe anxiety attacks, couldn't breathe, I stop taking it and was better. I told my reumatologist and he kind of scoffed at me and told me to try again. I did and same thing happened. Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Pinho de Oliveira Ribeiro N1, Rafael de Mello Schier A, Ornelas AC, Pinho de Oliveira CM, Nardi AE, Silva AC.