Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Novo-chloroquine 250 mg side effects Hydroxychloroquine bleeding and surgery Sep 13, 2019 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. diarrhea. dizziness. hair loss. headache. increased skin sensitivity to sunlight. loss of appetite. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Plaquenil side effects weight Will you have Weight loss with Plaquenil - eHealthMe, Plaquenil Side Effects on Your Eyes and Vision Is hydroxychloroquine safeOcular migraine plaquenil Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Plaquenil Side Effects - GoodRx. Plaquenil - Uses, Side Effects, Interactions -. Rx Side Effects New Plaquenil Guidelines and More.. Re want to know good stuff about plaquenil Sorry to be a party pooper here, but I have been on Plaquenil for 5 months and can't say I feel any difference at all. If anything I am sleeping all day but for just about 1 1/2 hours at a time. Aug 01, 2009 Lucy, meds effect us all differently. Almost any med that can cause weight loss can also cause weight gain. I also find that eating a lot of carbohydrates helps with the GI effects of the plaq and that can contribute to weight gain. I was on Plaquenil for 2 yrs and gained 60 pounds. The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given.