Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened. Hydroxychloroquine erg Hydroxychloroquine uses lupus Porphyria cutanea tarda commonly referred to as PCT is recognized as the most prevalent subtype of porphyritic diseases. The disease is characterized by onycholysis and blistering of the skin in areas that receive higher levels of exposure to sunlight. The primary cause of this disorder is a deficiency of uroporphyrinogen decarboxylase UROD, a cytosolic enzyme that is a step in the enzymatic pathway that leads to the synthesis of heme. Plaquenil hydroxychloroquine Disease Interactions. There are 8 disease interactions with Plaquenil hydroxychloroquine The use of 4-aminoquinolines is generally considered contraindicated in the presence of retinal or visual field changes, whether attributable to 4-aminoquinoline compounds or to any other etiology. Background High-dose hydroxychloroquine is rarely used in the treatment of porphyria cutanea tarda PCT. Objective The purpose of this study was to evaluate the efficacy and safety of a novel highdose hydroxychloroquine regimen in patients with PCT. If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years. Why hydroxychloroquine for porphyria cutanea tarda How are acute porphyria and porphyria cutanea tarda treated?, Plaquenil hydroxychloroquine Disease Interactions - Plaquenil ask doctorTaking plaquenil and ppiRetinal toxicity from plaquenil The treatment for Porphyria Cutanea Tarda involves a procedure called phlebotomy or by taking medication called hydroxychloroquine. Phlebotomy is a procedure in which blood is removed from the body so that the iron levels in the body becomes less which in turn helps in treatment of Porphyria Cutanea Tarda. Porphyria Cutanea TardaCausesSymptomsTreatmentDiagnosis. High-dose hydroxychloroquine treatment of porphyria cutane tarda.. Hydroxychloroquine MedlinePlus Drug Information. Porphyria cutanea tarda. A health care provider treats porphyria cutanea tarda by removing factors that tend to activate the disease and by performing repeated therapeutic phlebotomies to reduce iron in the liver. Therapeutic phlebotomy is the removal of about a pint of blood from a vein in the arm. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Six patients with skin changes and urinary porphyrin excretion patterns characteristic for porphyria cutanea tarda were treated with hydroxychloroquine sulfate therapy. During treatment periods ranging from five to 13 months, cutaneous symptoms disappeared and urinary porphyrin excretion abnormalities were completely or almost completely reversed.