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    Stendra is the newest, FDA-approved, erectile dysfunction (ED) prescription medication. By selectively targeting the key protein contributing to ED, Stendra treats ED with a lower rate of side effects compared to typical ED medications. Stendra is a second generation PDE-5 inhibitor that selectively targets the PDE-5 isoenzyme, the key protein in your body that contributes to ED. Because it primarily targets PDE-5, it has a low rate of side effects, is fast-acting Limit alcohol consumption to 3 servings when taking STENDRA. Drinking too much alcohol when taking STENDRA can increase your heart rate, lower blood pressure, and increase your chances of getting a headache or getting dizzy. However, you should take the lowest dose of STENDRA that works for you. You and your doctor should decide how much STENDRA to take and when to take it. (avanafil) is a prescription medicine used to treat erectile dysfunction (ED). It is not known if STENDRA is safe or effective in women or children under 18 years of age. (avanafil) is a prescription medicine used to treat erectile dysfunction (ED). It is not known if STENDRA is safe or effective in women or children under 18 years of age. can i buy prednisolone over the counter in uk Does not directly cause penile erections, but affects the response to sexual stimulation. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (c GMP), producing smooth muscle relaxation and inflow of blood to the corpus cavernosum. Avanafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE-5), which is responsible for degradation of c GMP in the corpus cavernosum; when sexual stimulation causes local release of NO, inhibition of PDE-5 by avanafil causes increased levels of c GMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum; at recommended doses, it has no effect in the absence of sexual stimulation. Rapid Hepatic via CYP3A4 (major), CYP2C (minor); forms metabolites (active and inactive) Feces (~62%); urine (~21%) Plasma: 30 to 45 minutes (fasting); 1.12 to 1.25 hours (high-fat meal) Terminal: ~5 hours ~99% In mild renal impairment, AUC decreased by 2.1%. Erectile dysfunction: Treatment of erectile dysfunction Hypersensitivity to avanafil or any component of the formulation; coadministration with any form of organic nitrates (either regularly and/or intermittently) or guanylate cyclase stimulators (eg, riociguat) Erectile dysfunction: Oral: Initial: 100 mg taken ~15 minutes prior to sexual activity; taken as one single dose and not more than once daily; dose may be increased to 200 mg ~15 minutes prior to sexual activity or decreased to 50 mg ~30 minutes prior to sexual activity using the lowest dose that provides benefit; maximum 200 mg daily Dosing adjustment with concomitant medications: Alpha-blocker (dose should be stable at time of avanafil initiation): Initial avanafil dose: 50 mg taken as one single dose and not more than once daily. Moderate CYP34A inhibitors (including amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil): Maximum avanafil dose: 50 mg taken as one single dose and not more than once daily.

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    Jul 8, 2014. Spedra tablets contain the active ingredient avanafil, which is a medicine used in the. The usual recommended dose of Spedra is 100mg. buy cialis johor bahru Feb 21, 2016. Only you can decide whether Stendra or Viagra works better for erectile. who took the recommended starting dosage of 100 mg of Stendra. Aug 29, 2012. Avanafil is dosed as 50 mg, 100 mg, or 200 mg tablets. Avanafil may differentiate itself from the other phosphodiesterase type 5 inhibitors with.

    Avanafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, avanafil works by increasing blood flow to the penis to help a man get and keep an erection. This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method (latex or polyurethane condom/dental dams) during all sexual activity. Consult your doctor or pharmacist for more details. Read the Patient Information Leaflet if available from your pharmacist before you start taking avanafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Avanafil is used to treat erectile dysfunction (ED: impotence; inability to get or keep an erection in men). Avanafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. Avanafil does not cure erectile dysfunction or increase sexual desire. Avanafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). For men taking the 100- mg or 200-mg doses, avanafil is usually taken with or without food as needed, about 15 minutes before sexual activity. For men taking the 50-mg dose, avanafil is usually taken with or without food as needed, about 30 minutes before sexual activity. Do not take avanafil more often than once in 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor.

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    Apr 1, 2014. All avanafil doses produced an improvement in IIEF-EF domain score compared with placebo. Again, the difference between avanafil 100mg. pfizer viagra cheap prices STENDRA, for oral administration, is supplied as oval, pale yellow tablets containing 50 mg, 100 mg, or 200 mg avanafil debossed with dosage strengths. The recommended starting dose is 100-mg. However, you should take the lowest dose of STENDRA that works for you. You and your doctor should decide how.

     
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