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The next step, for most women, is to call their GYNO and ask for fluconazole, known by many under the brand name Diflucan, or to retreat with a OTC topical. If you guessed correctly and aren’t better more of the same (i.e. trying fluconazole/Diflucan or another OTC medication) is not likely to be any better because the oral and topicals work in the same way. If you are not feeling better after treatment (which will happen 75% of the time just looking at the statistics) there are five possible scenarios: Put another way, if 100 women use OTC medication for vaginal yeast, 70 will have persistent symptoms because they never had yeast to begin with and 5 will still have persistent symptoms related to yeast. That means if you have persistent symptoms there is a 93% chance you never had yeast and a 7% chance that you did, but need further information to treat. The chance that more of the same will help is very slim. Other clinical pearls: A bad yeast infection can take seven days to feel a lot better, An antihistamine, like Zyrtec or Claritin, will help you feel better faster and a low dose topical steroid on the vulva (labia and vaginal opening) will also help if there is a lot of external irritation But the OTC always fails for me and the Diflucan always works! This is unlikely related to the type of medication (OTC vs prescription) and more a mechanical issue – some women place the vaginal medication too low in their vagina (if the tissues are really inflamed it can be harder to get high enough). Antiparasitic Antibiotics Antidepressants Antifungals Hypertension Cardiovascular Diseases Erectile Dysfunction Gastrointestinal Tract Mental Disorders Anti-inflammatories Osteoporosis Analgesics Respiratory Tract Women's Health Antifungals Generic Diflucan is an antifungal antibiotic. Do not take your medicine more often than directed. If it is almost time for your next dose, use only that dose. 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