About 120 million people around the world with Type 2 diabetes - and two million in Canada - take the drug metformin to control their disease. While doctors know metformin needs to interact with insulin to be effective, and that it can't lower blood sugar on its own, no one has been able to explain how and why this happens. Researchers at Mc Master University are the first to unlock that mystery with their discovery metformin works on fat in the liver. Their research is published in today's issue of the journal Nature Medicine. "The key is that metformin doesn't work to lower blood glucose by directly working on the glucose. It works on reducing harmful fat molecules in the liver, which then allows insulin to work better and lower blood sugar levels," said Greg Steinberg, associate professor in the Department of Medicine of the Michael G. He also holds the Canada Research Chair in Metabolism and Obesity and is a co-director of the Metabolism and Childhood (MAC)-Obesity Research Program. His research team included scientists in Alberta, Australia and Scotland. best cialis online order Hormonal levels are fine, blood fine, ultrasounds and all the other fancy xrays they do, fine. Until one day I was feeling that pain, and I drove to the hospital to have them give me an ultrasound, and there it was. So, if you've got a feeling that something is wrong, and it doesn't go away, don't give up!!!! I also recently found out I have non-alcoholic fatty liver(found this out along-side of PCOS). Finally diagnosed after years and years of "no findings". Apparently I'd been taking tests during the perfect times of everything being stable. Is it ok to take Metformin 500mg(just started) with that? Explain there are options available whatever the situation may be. 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Food and Drug Administration. Effect of metformin on caloric intake and body mass. Metformin is known to suppress feeding behavior 17,18 and excessive caloric intake might play a role in the genesis of obesity-related fatty. Since July last year, every day I ran 3.5 mile on a running machine. I tried to improve the situation by physical exercise. Sadly, weight was not reduced and a recent ultrasound exam showed fatty liver worsened. Further IGT test showed both glucose level and insulin level are moderately higher than normal. Doctor told me it is the case of insulin resistance associated with fatty liver. I feel quite discouraged that I really tried my best but could not see any improvement. Can anyone share the experience with me how to make things better with diet plus physical exercise? Two widely used medicines in China are Metformin and TZDs. Metformin hurts stomach and I already have serious stomach problems. 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I have non alcoholic fatty liver and am on 1700mg metformin 2x 850mg doctor doesn't seem to think it's a problem. tadalafil research Yep I have Fatty liver for 10 years and recently diagnosed as diabetic and I've been prescribed metformin. Only just starting so it sure of anything long term but I've read a lot of people take it with same conditions as me. On rare occasions, however, Metformin causes liver dysfunction and a serious metabolic condition involving the liver. For this reason.