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CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Sildenafil inhibits phosphodiesterase type-5 (PDE5) which is responsible for c GMP degradation in the corpus cavernosum. Caution when used in patients with anatomical deformation of penis or conditions that may predispose them to priapism (e.g. Mild, transient, dose-related impairment of colour discrimination (blue/green) may occur. Inhibition of PDE5 increases c GMP levels in the corpus cavernosum which results in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Hepatic or severe renal impairment, bleeding disorders, active peptic ulceration, hypotension, recent history of stroke, MI, arrhythmias, unstable angina, heart failure or retinal disorders. viagra chemical Suhagra is indicated for the treatment of erectile dysfunction. 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