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    Il presente articolo sul Sildenafil riporta le informazioni che è possibile reperire sul foglietto illustrativo del prodotto commerciale o sul sito della casa produttrice e dagli studi medici in bibliografia, non intende pubblicizzarne l'uso o promuoverlo in nessun modo, si ricorda di avere sempre la supervisione di un medico e di attenersi alle sue indicazioni, altresì le informazioni potrebbero essere non aggiornate per cui si consiglia di recarsi dal proprio medico o farmacista per ulteriori informazioni, inoltre si raccomanda di non fare acquisti su internet per la pericolosità di presunte farmacie e soprattutto senza un medico. Avere Possiamo dire come informazione primaria che Sildenafil agisce sulle strutture vascolari del pene, i cosiddetti "corpi cavernosi", favorendo l'afflusso di sangue all'interno di essi e di conseguenza permettendo l'erezione. La compressa di Sildenafil va assunta possibilmente lontana dal pasto; dopo circa 50 minuti, una sufficiente concentrazione del farmaco Sildenafil raggiunge i corpi cavernosi ed in presenza di eccitazione l'erezione risulterà facilitata; l'efficacia ha una durata che può andare dalle 4 alle 6 ore. Il farmaco Sildenafil viene metabolizzato a livello epatico da due citocromi: il citocromo 3A4 ed il citocromo 2C9. Il principale metabolita ottenuto è l’N-demetil sildenafil il quale è ancora farmacologicamente attivo (è in grado di inibire le 5PDE con una potenza, rispetto al sildenafil, del 50). Il rilassamento dei muscoli lisci dei corpi cavernosi dovuto al Sildenafil è mediato dall’ossido di azoto (NO) che attiva l’enzima guanilato ciclasi che catalizza la trasformazione della guanosina trifosfato o GTP in guanosina monofosfato ciclico o c GMP che stimola il rilasciamento muscolare. Ecco alcuni possibili comuni effetti collaterali di Sildenafil : mal di testa, stomaco agitato, infezioni del tratto urinario, sensibilità aumentata ai colori verde e rosso, diarrea, altri problemi, etc. amoxicillin hives If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice.

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    Viagra, Cialis, Levitra, and generic sildenafil are all part of a family of drugs called PDE-5 inhibitors. These drugs are used to treat erectile dysfunction (ED). Erectile dysfunction medication works by preventing the chemical process that lets blood leave an erect penis. Basically, PDE-5 inhibitors tip the chemical balance in the penis to favor getting and maintaining an erection. The biggest difference between Viagra and generic sildenafil is the amount of active ingredient in each pill. The other main difference is that generic sildenafil is FDA approved to treat Pulmonary Hypertension (that’s high blood pressure between the heart and lungs) while Viagra is FDA approved to treat erectile dysfunction. It’s a little confusing since both medications use the same active ingredient, but Viagra and sildenafil work in the same way. When a man is sexually excited, the penis rapidly fills with more blood than usual. With this extra flow of blood, the penis then expands and hardens. After the man is done having sex, this extra blood flows out of the penis back into the body. In an opposite extreme situation, if an erection lasts for a long time (more than 6 hours), it can permanently damage your penis. You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours. Therefore sexual activity may not be advisable for people who have heart problems. Before you start any treatment for erectile dysfunction, ask your doctor if your heart is healthy enough to handle the extra strain of having sex. If you have chest pains, dizziness or nausea during sex, stop having sex and immediately tell your doctor you have had this problem. This is called erectile dysfunction if it becomes a frequent problem. Erectile dysfunction is a serious problem that can affect both the young and the old, involving psychological causes in some cases. Among other treatments that are nowadays available for erectile dysfunction, Viagra was the first. Some conditions and medicines interfere with the natural erection process. Erectile dysfunction, defined today as the inability to attain and maintain an erect penis with sufficient rigidity for sexual intercourse, has become an increasingly common complaint that affects 140 million men worldwide. So Viagra stands out as the pioneer of drugs that treat erectile dysfunction, for twenty years. Sildenafil citrate was the first oral agent to be introduced for the treatment of erectile dysfunction, thanks to the researchers from Pfizer. Sildenafil is the active substance of Viagra, while Viagra is the commercial name. Teva’s generic Viagra has launched already in December 2017 in the United States. Risk factors for developing erectile dysfunction include age, diabetes, hypertension, obesity, lack of exercise, dyslipidemia, smoking, depression, lower urinary tract symptoms, and pelvic surgery. Sildenafil is a highly selective inhibitor of PDE type 5 and enhances NO-mediated relaxation of human corpus cavernosum. Pfizer recently started to sell the new generic version of Viagra.

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